If you have information about a current study or fellowship opportunity relating to pediatric stroke that you would like added to our Research page, please to send us your trial title and clinicaltrials.gov link. IAPS can help with participant recruitment or disseminating your study information, so we encourage young investigators to .
Current Clinical Trials
Combining behavioral therapies, constraint-induced movement therapy (CIMT), with a novel form of neuromodulation, transcranial direct current stimulation (tDCS), we will investigate the influence of this intervention on improved motor outcomes in children with cerebral palsy. The study hypotheses surround the safety, feasibility and efficacy of combined CIMT and tDCS wherein those children who receive the combined intervention will reveal no major adverse events, yet improved hand function and cortical excitability. Ages Eligible for Study: 8 Years to 21 Years. Inclusion criteria includes: Hemispheric Stroke or Periventricular Leukomalacia confirmed by most recent MRI or CT radiologic report with resultant congenital hemiparesis; No evidence of seizure activity within the last 2 years. Two locations: University of Minnesota, Minneapolis, Minnesota, United States and Gillette Children's Specialty Healthcare, St. Paul, Minnesota, United States. Recruitment flyer
The International Pediatric Stroke Study is a multi-center collaborative study to establish a database of information about stroke in infants and children.
Children 0 to 18 years of age who: 1) have had an ischemic stroke after January 1, 2003; 2) have a history of spastic hemiplegic or quadriplegic cerebral palsy and X-ray evidence of ischemic stroke after January 1, 2003; or 3) are diagnosed with ischemic stroke defined by a new focal neurologic deficit lasting 24 hours or more and presumed due to vessel obstruction or narrowing may be eligible to participate this study.
Participating children have their medical and research records reviewed for information about their stroke. The information is gathered and entered into an internet database. Parents may be interviewed to obtain additional information, if needed. No identifying information is entered into the database, so that the child's participation remains anonymous. The resulting registry may allow physicians to better diagnose, treat, and prevent stroke in children, and will help in developing and conducting new clinical trials to study this disease. For more information, please reference the International Pediatric Stroke Study information sheet
National Egyptian Network Pediatric Stroke and Hemiplegia Registry, ClinicalTrials.gov NCT02129491The aim is to establish multi-center national Egyptian database of information about cerebrovascular stroke and hemiplegia in infants and children from 0 to 18 years of age. Inclusion criteria: Focal neurological deficit of acute onset lasting greater than 20 minutes. And CT or MRI showing infarct in location consistent with neurological signs and symptoms; Hemiplegia.
Pediatric Department, Children's Hospital, Faculty of Medicine, Ain Shams University
Cairo, Abassia, Egypt
The CHAMP Study is a multisite clinical trial funded by the National Institutes of Health that is comparing the efficacy of alternative therapies for young children with unilateral spastic cerebral palsy (or hemiparetic cerebral palsy). Children who meet study eligibility criteria at one of the three clinical sites (Roanoke, VA; Charlottesville, VA, and Columbus, OH) will be invited to enroll, and their parents will be provided all necessary paperwork along with informed consent documentation. Inclusion Criteria: 2 years - 8 years old, do not have any serious complicating conditions or acute medical concerns, are diagnosed with cerebral palsy with hemiparesis (prior to age 2), have not had botox injections in the last 6 months and have not received Constraint-Induced Movement Therapy in the last 6 months, have a clinical MRI that can be provided in digital format for research project.
Asymmetrical Gait Training After Pediatric Stroke,
The purposes of this pilot research study are 1. To begin to test if two different types of physical therapy might have different results in children and adolescents who have had a prior stroke, and 2. To determine if either type of physical therapy causes changes in the brain signals that control leg muscles. Recruiting ages 5 – 17 years, onset of stroke after 2 years of age and at least 6 months before study enrollment. Study being conducted at Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.
Modulation of Brain Plasticity after Perinatal Stroke (PLASTIC CHAMPS),
A special study to test constraint-induced movement therapy (CIMT), and a type of non-invasive brain stimulation called transcranial magnetic stimulation (TMS) to modulate brain plasticity toward better function in children with stroke-induced Cerebral Palsy. Children 7-18 years with stroke-induced CP will be recruited into the study from across Alberta, Canada.
The Vascular Effects of Infection in Pediatric Stroke (VIPS) Study,
The multicenter Vascular Effects of Infection in Pediatric Stroke (VIPS) cohort study will test the hypotheses that (1) infection can lead to childhood arterial ischemic stroke by causing vascular injury and (2) resultant arteriopathy and inflammatory markers predict recurrent stroke. The authors are prospectively enrolling 480 children (aged 1 month through 18 years) with arterial ischemic stroke. Location is San Francisco, California.
Optical Measurement of Cerebral Hemodynamics in Children With Acute Arterial Ischemic Stroke,
Acute ischemic stroke affects roughly 1 in 50,000 children every year and is one of the top ten causes of death in children. Currently, caregivers lay the affected child flat in hopes of increasing blood flow to the brain and reducing the volume of the brain which is damaged. However, there are currently no techniques to measure brain blood flow at the child's bedside and indicate if this treatment is effective. We will probe brain blood volume, oxygen saturation, and flow with red light to determine the efficacy of this intervention.
Location: Children’s Hospital of Philadelphia, Philadelphia, PA. Eligibility requirements include: subjects age 2-18 years inclusive; 72 hours or less from stroke onset; no history of congenital or acquired brain injury; no history of developmental delay, mental retardation, genetic or metabolic syndrome affecting the brain.
Intensive Motor Training After Perinatal Stroke To Enhance Walking,
Early childhood injuries such as perinatal (around birth) stroke are devastating because the child lives with the problem for life, typically close to a normal lifespan. One 'opportunity' presented by a brain injury early in life compared to later in adulthood is that the young brain is much more plastic (malleable) and receptive to interventions. We will test the hypothesis that early (<2 yr old), intensive leg training will improve walking more than no training or training at >2 yr old. We will further determine the changes induced by training in motor and sensory pathways.
Location: University of Alberta. Eligibility requirements include: 8 months to 4 years of age; hemiplegia with confirmation of perinatal stroke; born near term.
Current Fellowship Opportunities
Alberta Children's Hospital (Calgary, Alberta, Canada)
The Calgary Pediatric Stroke Program has research training opportunities available. Current research trainees include post-graduate clinical research fellows, neuroscience and psychology graduate students, neuroscience nursing, resident physicians, medical students, and undergraduates. Additional information on CPSP Research Programs is available . For more information, please contact Dr. Adam Kirton at
Children’s Hospital Of Philadelphia
The pediatric stroke fellowship program at CHOP is under Dr. Rebecca Ichord’s direction and details for any future opportunities will be available by contacting Dr. Ichord at: email@example.com
, or calling the Pediatric Stroke Program office at 215-590-4142.
Sick Kids Hospital (Toronto, Canada)
Recruitment is expected to begin again in 2014 or 2015. Please click for more details about Sick Kids Hospital opportunities. Or contact:
Gabrielle deVeber MD
Professor of Pediatrics
Director, Children's Stroke Program
Division of Neurology
Hospital for Sick Children
University of California, San Francisco Medical Center
UCSF has a single one-year vascular neurology (stroke) fellowship, ACGME accredited, that either adult or child neurologists can complete. It is adult stroke oriented, with a component of childhood stroke (including mentorship by a pediatric stroke neurologist, Dr. Heather Fullerton) for the pediatric trainees. The fellow is board-eligible in Vascular Neurology (by the American Board of Psychiatry and Neurology) upon completion.
The fellowship began in the early 1990’s and has had a total of 3 pediatric stroke trainees: Heather Fullerton (2002-2003), Christine Fox (2010-2011), and Kevin Shapiro (2013-2014).
For more information please go to their website at or contact Dr. Heather Fullerton at or Michelle Cereghino (Education Coordinator) at
Pediatric Stroke Research Centers
Alberta Children's Hospital
Contact: Dr. Adam Kirton,
Children's Hospital of Philadelphia (Philadelphia, Pennsylvania)
Contact: Dr. Rebecca Ichord,
Maimonides Research Foundation (Brooklyn, New York)
Contact: Stephen Pavlakis,
University of California at San Francisco (San Francisco, California)
Contact: Dr. Heather Fullerton,
Contact: Dr. Christine Fox,
University of Colorado/Children's Hospital Colorado (Denver, Colorado)
Contact: Jennifer Armstron-Wells,
Contact: Timothy Bernard,
Université de Sherbrooke (Sherbrooke, Quebec, Canada)
Contact: Guillaume Sébire, MD, PhD,
University of Texas Southwestern Medical Center at Dallas (Dallas, Texas)
Contact: Dr. Michael M. Dowling,
West Virginia University (Morgantown, West Virginia)
Contact: Paola Pergami,
Potential Funding Options
Patient-Centered Outcomes Research Institute, (PCORI) , is a non-profit agency in
the U.S. that awards funding to comparative clinical effectiveness research
that will give patients and those who care for them the ability to make
better-informed health decisions. Applications from outside the U.S. will be accepted, but the research has to provide a benefit for the U.S. population. PCORI has 3
funding cycles per year and they will be providing funding through 2019. You
can register for their newsletter or check their website to find the upcoming
dates for application deadlines, as well as more details on what the
requirements are for submission. PCORI requires
that the proposals they fund include patients and other stakeholders in
each step of the research process - from proposal development to research design
and dissemination of the study results. To learn more about submitting an application to PCORI pertaining to
pediatric stroke please .
Disclaimer: The International Alliance for Pediatric Stroke acknowledges this is not an all-inclusive list of pediatric stroke studies/fellowships that are available worldwide. Please search ClinicalTrials.gov with key words "pediatric stroke" for more clinical trials.
We invite researchers, scientists, investigators, physicians, etc. to update us on any facilities, studies, trials or fellowships by requesting an IAPS .