If you have information about a current study or fellowship opportunity relating to pediatric stroke that you would like added to our Research page, please click here to send us your trial title and clinicaltrials.gov link. IAPS can help with participant recruitment or disseminating your study information, so we encourage young investigators to contact us.

Current Clinical Trials

Perinatal Stroke: Understanding Brain Reorganization, (ClinicalTrials.gov NCT02743728
The incidence of perinatal stroke is relatively common, as high as 1 in 2,300 births, but little is known about the resulting changes in the brain that eventually manifest as cerebral palsy (CP). More importantly, no therapy has been devised to mitigate these specific maladaptive changes leading to hemiplegic CP. However, motor signs that indicate the infant is beginning to develop CP often do not become evident for several months after the diagnosis of perinatal stroke. This delays therapy. We view the first several months after perinatal stroke as a "window of opportunity" because it is known to be a critical period of development. 
Location: University of Minnesota, Minneapolis, MN, United States
Inclusion Criteria:
  • Birth diagnosis of unilateral perinatal stroke by cranial ultrasound, computer tomography (CT) or magnetic resonance imaging (MRI)
  • Corrected gestational age between 3 and 12 months of age
More information can be found on the Recruitment Flyer and Perinatal Brochure
Database for Strokes in Infants and Children, ClinicalTrials.gov NCT00084292
The International Pediatric Stroke Study is a multi-center collaborative study to establish a database of information about stroke in infants and children.
Children 0 to 18 years of age who: 1) have had an ischemic stroke after January 1, 2003; 2) have a history of spastic hemiplegic or quadriplegic cerebral palsy and X-ray evidence of ischemic stroke after January 1, 2003; or 3) are diagnosed with ischemic stroke defined by a new focal neurologic deficit lasting 24 hours or more and presumed due to vessel obstruction or narrowing may be eligible to participate this study.
Participating children have their medical and research records reviewed for information about their stroke. The information is gathered and entered into an internet database. Parents may be interviewed to obtain additional information, if needed. No identifying information is entered into the database, so that the child's participation remains anonymous. The resulting registry may allow physicians to better diagnose, treat, and prevent stroke in children, and will help in developing and conducting new clinical trials to study this disease. For more information, please reference the International Pediatric Stroke Study information sheet.
National Egyptian Network Pediatric Stroke and Hemiplegia Registry, ClinicalTrials.gov NCT02129491
The aim is to establish multi-center national Egyptian database of information about cerebrovascular stroke and hemiplegia in infants and children from 0 to 18 years of age. Inclusion criteria: Focal neurological deficit of acute onset lasting greater than 20 minutes. And CT or MRI showing infarct in location consistent with neurological signs and symptoms; Hemiplegia.
Location: Pediatric Department, Children's Hospital, Faculty of Medicine, Ain Shams University
Cairo, Abassia, Egypt
Descriptive Analysis of Near Infrared Spectroscopy in Critically Ill and Injured Pediatric and Neonatal Patients (NIRSCI), ClinicalTrials.gov NCT02950181 
This study involves looking at Cerebral oximetry measurements in pediatric and neonatal patients who are experiencing a critical illness. Such as Altered mental status, seizures, trauma, sepsis, etc. Ages Eligible for Study: up to 21 Years. Location: Arkansas Children's Hospital, Little Rock, Arkansas, United States
AOT and ICT for Hemiplegia (Tele-UPCAT), ClinicalTrials.gov NCT03094455
A new rehabilitative approach, called AOT, based on the recent discovery of mirror neuron system (MNS), has been used with promising results on the Upper Limb (UL) function in some studies in children with Cerebral Palsy (CP).The purpose of the present trial is to provide evidence by a RCT that AOT is an effective rehabilitation tool in Children with Unilateral CP (UCP) and that its effects are greater than standard care. Ages Eligible for Study: 5 Years to 20 Years. Location, Italy.
Children with Hemiparesis Arm and Hand Movement Project (CHAMP Study), ClinicalTrials.gov NCT01895660
(Active not recruiting) The CHAMP Study is a multisite clinical trial funded by the National Institutes of Health that is comparing the efficacy of alternative therapies for young children with unilateral spastic cerebral palsy (or hemiparetic cerebral palsy). Children who meet study eligibility criteria at one of the three clinical sites (Roanoke, VA; Charlottesville, VA, and Columbus, OH) will be invited to enroll, and their parents will be provided all necessary paperwork along with informed consent documentation. Inclusion Criteria:  2 years - 8 years old, do not have any serious complicating conditions or acute medical concerns, are diagnosed with cerebral palsy with hemiparesis (prior to age 2), have not had botox injections in the last 6 months and have not received Constraint-Induced Movement Therapy in the last 6 months, have a clinical MRI that can be provided in digital format for research project.

Optical Measurement of Cerebral Hemodynamics in Children With Acute Arterial Ischemic Stroke, ClinicalTrials.gov NCT01786785
Acute ischemic stroke affects roughly 1 in 50,000 children every year and is one of the top ten causes of death in children. Currently, caregivers lay the affected child flat in hopes of increasing blood flow to the brain and reducing the volume of the brain which is damaged. However, there are currently no techniques to measure brain blood flow at the child's bedside and indicate if this treatment is effective. We will probe brain blood volume, oxygen saturation, and flow with red light to determine the efficacy of this intervention.

Location: Children’s Hospital of Philadelphia, Philadelphia, PA. Eligibility requirements include: subjects age 2-18 years inclusive; 72 hours or less from stroke onset; no history of congenital or acquired brain injury; no history of developmental delay, mental retardation, genetic or metabolic syndrome affecting the brain.

Intensive Motor Training After Perinatal Stroke To Enhance Walking, ClinicalTrials.gov NCT01773369
(Active not recruiting) Early childhood injuries such as perinatal (around birth) stroke are devastating because the child lives with the problem for life, typically close to a normal lifespan. One 'opportunity' presented by a brain injury early in life compared to later in adulthood is that the young brain is much more plastic (malleable) and receptive to interventions. We will test the hypothesis that early (<2 yr old), intensive leg training will improve walking more than no training or training at >2 yr old. We will further determine the changes induced by training in motor and sensory pathways.

Location: University of Alberta. Eligibility requirements include: 8 months to 4 years of age; hemiplegia with confirmation of perinatal stroke; born near term.

Current Fellowship Opportunities 

Alberta Children's Hospital (Calgary, Alberta, Canada)
The Calgary Pediatric Stroke Program has research training opportunities available. Current research trainees include post-graduate clinical research fellows, neuroscience and psychology graduate students, neuroscience nursing, resident physicians, medical students, and undergraduates. For more information, please contact Dr. Adam Kirton at adam.kirton@albertahealthservices.ca

Children’s Hospital Of Philadelphia
The pediatric stroke fellowship program at CHOP is under Dr. Rebecca Ichord’s direction and details for any future opportunities will be available by contacting Dr. Ichord at: ichord@email.chop.edu, or calling the Pediatric Stroke Program office at 215-590-4142.
Sick Kids Hospital (Toronto, Canada)
Recruitment is expected to begin again in 2014 or 2015. Please click here for more details about Sick Kids Hospital opportunities. Or contact:
Gabrielle deVeber MD
Professor of Pediatrics
Director, Children's Stroke Program
Division of Neurology
Hospital for Sick Children
phone: 416-813-7721
fax: 416-813-6334

University of California, San Francisco Medical Center
UCSF has a single one-year vascular neurology (stroke) fellowship, ACGME accredited, that either adult or child neurologists can complete.  It is adult stroke oriented, with a component of childhood stroke (including mentorship by a pediatric stroke neurologist, Dr. Heather Fullerton) for the pediatric trainees. The fellow is board-eligible in Vascular Neurology (by the American Board of Psychiatry and Neurology) upon completion. 

The fellowship began in the early 1990’s and has had a total of 3 pediatric stroke trainees:  Heather Fullerton (2002-2003), Christine Fox (2010-2011), and Kevin Shapiro (2013-2014).

For more information please contact Dr. Heather Fullerton at FullertonH@neuropeds.ucsf.edu or Michelle Cereghino (Education Coordinator) at Michelle.Cereghino@ucsf.edu

Pediatric Stroke Research Centers

Alberta Children's Hospital
Contact: Dr. Adam Kirton, adam.kirton@albertahealthservies.ca 
Children's Hospital of Philadelphia (Philadelphia, Pennsylvania)
Contact: Dr. Rebecca Ichord, ichord@emailchop.edu
University of Minnesota (Minneapolis, Minnesota)
Gillick Pediatric Lab
Contact: Maureen Boxrud, brown029@umn.edu 
Maimonides Research Foundation (Brooklyn, New York) 
University of California at San Francisco (San Francisco, California)
Contact: Dr. Heather Fullerton, fullertonh@neuropeds.ucsf.edu
Contact: Dr. Christine Fox, foxc@neuropeds.ucsf.edu 
University of Colorado/Children's Hospital Colorado (Denver, Colorado)
Contact: Jennifer Armstron-Wells, jennifer.armstrong-wells@ucdenver.edu
Contact: Timothy Bernard, timothy.bernard@ucdenver.edu 
University of Texas Southwestern Medical Center at Dallas (Dallas, Texas)
Contact: Dr. Michael M. Dowling, michael.dowling@utsouthwestern.edu
West Virginia University (Morgantown, West Virginia)
Contact: Paola Pergami, ppergami@hsc.wvu.edu

Potential Funding Options

The Patient-Centered Outcomes Research Institute, (PCORI) www.pcori.org, is a non-profit agency in the U.S. that awards funding to comparative clinical effectiveness research that will give patients and those who care for them the ability to make better-informed health decisions. Applications from outside the U.S. will be accepted, but the research has to provide a benefit for the U.S. population. PCORI has 3 funding cycles per year and they will be providing funding through 2019. You can register for their newsletter or check their website to find the upcoming dates for application deadlines, as well as more details on what the requirements are for submission. PCORI requires that the proposals they fund  include patients and other stakeholders in each step of the research process - from proposal development to research design and dissemination of the study results. To learn more about submitting an application to PCORI pertaining to pediatric stroke please contact us.

Disclaimer: The International Alliance for Pediatric Stroke acknowledges this is not an all-inclusive list of pediatric stroke studies/fellowships that are available worldwide. Please search ClinicalTrials.gov with key words "pediatric stroke" for more clinical trials.

We invite researchers, scientists, investigators, physicians, etc. to update us on any facilities, studies, trials or fellowships by requesting an IAPS registration form

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